Purinergic regulation of microglial mobility and viability during ischemic conditions in developing mouse brain tissues
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چکیده
Approved: _______________________________________________________ Thesis Supervisor _______________________________________________________ Title and Department ________________________________________________________ Date PURINERGIC REGULATION OF MICROGLIAL MOBILITY AND VIABILITY DURING ISCHEMIC CONDITIONS IN DEVELOPING MOUSE BRAIN TISSUES by Ukpong Bassey Eyo A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Biology in the Graduate College of The University of Iowa
منابع مشابه
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Brain-resident microglia may promote tissue repair following stroke but, like other cells, they are vulnerable to ischemia. Here we identify mechanisms involved in microglial ischemic vulnerability. Using time-lapse imaging of cultured BV2 microglia, we show that simulated ischemia (oxygen-glucose deprivation; OGD) induces BV2 microglial cell death. Removal of extracellular Ca(2+) or applicatio...
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تاریخ انتشار 2016